Bio-Connect

anti-KIR2D antibody [NKVFS1] (PE)

Research Use Only
ARG22540
Arigo Biolaboratories
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetKIR2DS1
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-KIR2D antibody [NKVFS1] (PE)
  • Delivery Days Customer
    23
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    NKVFS1
  • Conjugate
    RPE
  • Gene ID3806
  • Target name
    KIR2DS1
  • Target description
    killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1
  • Target synonyms
    CD158 antigen-like family member H; CD158a; CD158H; killer cell immunoglobulin-like receptor 2DS1; killer cell immunoglobulin-like receptor KIRDS1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1; killer-cell immunoglobulin-like receptor; KIR2DS1 Killer-cell Immunoglobulin-like Receptor; MHC class I NK cell receptor Eb6 ActI; p50.1
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203