anti-LIME antibody [mLIME-05]
ARG63063
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityMouse
TargetLime1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-LIME antibody [mLIME-05]
- Delivery Days Customer23
- ApplicationsImmunoPrecipitation, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDmLIME-05
- Concentration1 mg/ml
- ConjugateUnconjugated
- Estimated Purity>95%
- Gene ID72699
- Target nameLime1
- Target descriptionLck interacting transmembrane adaptor 1
- Target synonyms2810038K19Rik; lck-interacting molecule; lck-interacting transmembrane adapter 1; LI; LIME
- HostMouse
- IsotypeIgG2a
- Scientific DescriptionLIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
- ReactivityMouse
- Storage Instruction-20°C
- UNSPSC12352203