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anti-LIME antibody [mLIME-05]

Research Use Only
ARG63063
Arigo Biolaboratories
ApplicationsImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityMouse
TargetLime1
Price on request
Packing Size
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Overview

  • Supplier
    Arigo Biolaboratories
  • Product Name
    anti-LIME antibody [mLIME-05]
  • Delivery Days Customer
    23
  • Applications
    ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    mLIME-05
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Estimated Purity
    >95%
  • Gene ID72699
  • Target name
    Lime1
  • Target description
    Lck interacting transmembrane adaptor 1
  • Target synonyms
    2810038K19Rik; lck-interacting molecule; lck-interacting transmembrane adapter 1; LI; LIME
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.
  • Reactivity
    Mouse
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203