anti-NAIP1/2/5 (mouse), mAb (Naipa-1)

Catalog number: AG-20B-0045-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 360.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-NAIP1/2/5 (mouse), mAb (Naipa-1)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot
Species: Mouse
Target: Naip5
Target description: NLR family, apoptosis inhibitory protein 5
Clonality: Monoclonal
Isotype: IgG2b Kappa
Source: Purified from concentrated hybridoma tissue culture supernatant.
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: Monoclonal Antibody. Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain. Isotype: Mouse IgG2bkappa. Clone: Naipa-1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK. - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Clone ID: Naipa-1
Gene ID: 17951
Swiss prot ID: Q9R016
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: baculoviral IAP repeat-containing 1e; baculoviral IAP repeat-containing protein 1e; Birc1e; Legionella, susceptiblility 1; Lgn1; Naip-rs3; neuronal apoptosis inhibitory protein 5; neuronal apoptosis inhibitory protein, related sequence 3