anti-NLRP1/NALP1 (human), pAb (AL176)

Catalog number: AG-25B-0005-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 295.00
Expected delivery time: 7 days

Product specifications for - anti-NLRP1/NALP1 (human), pAb (AL176)

Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot
Clonality: Polyclonal
Source: Rabbit
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions: Store at -20°C
Scientific information: 
Scientific info: NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.
Swiss prot ID: Q9C000
Safety information: 
Additional information: 
Synonyms: AG-25B-0005-C100; AdipoGen Life Sciences; NACHT-, LRR- and PYD-containing Protein 1; NLRP1; Caspase Recruitment Domain-containing Protein 7; Death Effector Filament-forming Ced-4-like Apoptosis Protein; Nucleotide-binding Domain and Caspase Recruitment Domain
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon, et al.; Mol. Cell. 10, 417 (2002) Read more