anti-NLRP3/NALP3, mAb (Cryo-2)

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Product specifications for - anti-NLRP3/NALP3, mAb (Cryo-2)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoHistoChemistry; ImmunoPrecipitation; Western Blot
Species:	Human, Mouse
Target:	Nlrp3
Target description:	NLR family, pyrin domain containing 3
Isotype:	IgG2b
Source:	Purified from concentrated hybridoma tissue culture supernatant.

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	-20-¦C

Scientific information:
Scientific info:	Monoclonal Antibody. Recognizes mouse and human NLRP3/NALP3. Isotype: Mouse IgG2b. Clone: Cryo-2. Applications: IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
Clone ID:	Cryo-2
Gene ID:	216799
Swiss prot ID:	Q8R4B8

Safety information:
MSDS:	MSDS

Additional information:
Synonyms:	AGTAVPRL; AII/AVP; Cias1; cold autoinflammatory syndrome 1 protein homolog; cryopyrin; FCAS; FCU; mast cell maturation-associated-inducible protein 1; Mmig1; MWS; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; Pypaf1; PYRIN-containing APAF1-like protein 1

Thioredoxin-interacting protein links oxidative stress to inflammasome activation: R. Zhou, et al.; Nature Immunology 11, 136 (2010)

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD: A. Vilaysane, et al.; J. Am. Soc. Nephrol. 21, 1732 (2010)

A role for mitochondria in NLRP3 inflammasome activation: R. Zhou, et al.; Nature 469, 221 (2011)

Differential expression of NLRP3 among hematopoietic cells: G. Guarda, et al.; J. Immunol. 186, 2529 (2011)

Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A: C.A. Embry, et al.; Sci. Signal. 4, ra28 (2011)

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1 Secretion: N. Komune, et al.; J. Virol. 85, 13019 (2011)

Novel role of PKR in inflammasome activation and HMGB1 release: B. Lu, et al.; Nature 488, 670 (2012)

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity: B.F. Py, et al.; Mol. Cell 49, 331 (2012)

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice: M.T. Heneka, et al.; Nature 493, 67 (2012)

Activation of autophagy by inflammatory signals limits IL-1b production by targeting ubiquitinated inflammasomes for destruction: C.-S. Shi, et al.; Nat. Immunol. 13, 255 (2012)

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Product specifications for - anti-NLRP3/NALP3, mAb (Cryo-2)