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anti-NS5B (HCV), mAb (blocking) (5B-12B7)

Research Use Only
AG-20B-0003
AdipoGen Life Sciences
ApplicationsImmunoPrecipitation, ImmunoCytoChemistry, Neutralisation/Blocking
Product group Antibodies
ReactivityVirus
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-NS5B (HCV), mAb (blocking) (5B-12B7)
  • Delivery Days Customer
    10
  • Applications
    ImmunoPrecipitation, ImmunoCytoChemistry, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5B-12B7
  • Concentration
    1 mg/ml
  • Estimated Purity
    >95%
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    Monoclonal Antibody. Recognizes HCV NS5B from HCV genotype 1 (epitope mapped to NS5B aa 139-392). Does not react with genotype 2. Isotype: Mouse IgG2a. Clone: 5B-12B7. Applications: FUNC (Blocking), ICC, IP. Liquid. In PBS containing 0.02% sodium azide. The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs. - The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
  • Reactivity
    Virus
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203