anti-p15 INK4b antibody [DCS114.1]

Arigo Biolaboratories

anti-p15 INK4b antibody [DCS114.1]

23

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

DCS114.1

Unconjugated

CDKN2B

cyclin dependent kinase inhibitor 2B

CDK inhibitory protein; CDK4B inhibitor; CDK4I; cyclin-dependent kinase 4 inhibitor B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4B; MTS2; MTS-2; multiple tumor suppressor 2; p14_CDK inhibitor; p14_INK4B; p14-INK4b; P15; p15 CDK inhibitor; p15_INK4B; p15INK4b; p15-INK4b; TP15

Mouse

IgG1

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

Human

-20°C

12352203