anti-PD-1 (mouse), mAb (blocking) (1H10)

Catalog number: AG-20B-0075-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 190.00
Expected delivery time: 7 days
Quantity:
anti-BAFF (mouse), mAb (Sandy-2) (P...

Product specifications for - anti-PD-1 (mouse), mAb (blocking) (1H10)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Flow Cytometry; Neutralisation/Blocking
Clonality: Monoclonal
Isotype: IgG2a Kappa
Source: Purified from concentrated hybridoma tissue culture supernatant.
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Storage instructions: Short +4°C, long -20°C.
Scientific information: 
Scientific info: CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases. - Monoclonal Antibody. Recognizes mouse PD-1 (CD279). Does not cross-react with human PD-1d. Isotype: Rat IgG2akappa. Clone: 1H10. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 0.02% sodium azide. CD279 (Programmed Cell Death Protein 1; PD-1) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T cells, B cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
Clone ID: 1H10
Safety information: 
MSDS: MSDS
Antibody-mediated signalling through PD-1 costimulates T cells and enhances CD28- dependent proliferation: M.L. del Rio, et al.; Eur. J. Immunol. 35, 3545 (2005) Read more