anti-RAB8A antibody
ARG64473
ApplicationsWestern Blot
Product group Antibodies
ReactivityBovine, Canine, Human
TargetRAB8A
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-RAB8A antibody
- Delivery Days Customer23
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5 mg/ml
- ConjugateUnconjugated
- Gene ID4218
- Target nameRAB8A
- Target descriptionRAB8A, member RAS oncogene family
- Target synonymsMEL; mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; mel transforming oncogene (RAB8 homolog); oncogene c-mel; RAB8; ras-associated protein RAB8; ras-related protein Rab-8A
- HostGoat
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
- ReactivityBovine, Canine, Human
- Storage Instruction-20°C
- UNSPSC12352203