anti-ROCK1 antibody
ARG56252
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetROCK1
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-ROCK1 antibody
- Delivery Days Customer23
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID6093
- Target nameROCK1
- Target descriptionRho associated coiled-coil containing protein kinase 1
- Target synonymsp160 ROCK-1; P160ROCK; renal carcinoma antigen NY-REN-35; rho-associated protein kinase 1; ROCK-I
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015]
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203