anti-Sirtuin 6 (human), mAb (S6R82-2)

AdipoGen Life Sciences

anti-Sirtuin 6 (human), mAb (S6R82-2)

10

Western Blot, ELISA

Research Use Only

Monoclonal

S6R82-2

1 mg/ml

SIRT6

sirtuin 6

NAD-dependent protein deacetylase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2L6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6

Mouse

IgG2b

Monoclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~47kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S6R82-2. Applications: ELISA, WB. Liquid. 0.2microm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha. - Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

Human

2°C to 8°C,-20°C

12352203