anti-Sirtuin 6 (human), pAb

AdipoGen Life Sciences

anti-Sirtuin 6 (human), pAb

10

Western Blot, ELISA

Research Use Only

Polyclonal

1 mg/ml

SIRT6

sirtuin 6

NAD-dependent protein deacetylase sirtuin-6; regulatory protein SIR2 homolog 6; SIR2L6; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6

Rabbit

Polyclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~42kDa by Western blot. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2microm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha. - Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

Human

2°C to 8°C,-20°C

12352203