anti-Smac / Diablo antibody
ARG54330
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetDIABLO
Overview
- SupplierArigo Biolaboratories
- Product Nameanti-Smac / Diablo antibody
- Delivery Days Customer23
- ApplicationsWestern Blot, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID56616
- Target nameDIABLO
- Target descriptiondiablo IAP-binding mitochondrial protein
- Target synonymsDFNA64; diablo homolog, mitochondrial; diablo-like protein; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase; SMAC
- HostRabbit
- IsotypeIgG
- Scientific DescriptionInhibitors of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases has been identified and designated Smac/DIABLO. Smac is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. The N-terminal amino acids of Smac are required for binding to IAPs and for activation of caspases. Smac is expressed in a variety of human and mouse tissues.
- ReactivityHuman
- Storage Instruction-20°C
- UNSPSC12352203