anti-SUR1 / ABCC8 antibody

Arigo Biolaboratories

anti-SUR1 / ABCC8 antibody

23

Western Blot

Research Use Only

Polyclonal

0.5 mg/ml

Unconjugated

ABCC8

ATP binding cassette subfamily C member 8

ABC36; ATP-binding cassette sub-family C member 8; ATP-binding cassette transporter sub-family C member 8; ATP-binding cassette, sub-family C (CFTR/MRP), member 8; HHF1; HI; HRINS; MRP8; PHHI; PNDM3; sulfonylurea receptor (hyperinsulinemia); sulfonylurea receptor 1; SUR; SUR1; SUR1delta2; TNDM2

Goat

IgG

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008]

Canine, Human, Mouse, Rat

-20°C

12352203