Anti-Synapsin I Antibody

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Product specifications for - Anti-Synapsin I Antibody

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	Western Blot
Application note:	Western blotting: 1:200-1:1,000 dilution of a previous lot was used.Immunocytochemistry: 1:500-1:2,000 dilution of a previous lot was used.Immunoprecipitation: 1 ug of a previous lot immunoprecipitated all of the synapsin I from a SDS homogenate of 200 ug of rat brain protein.Note: The above dilutions are with 35S-protein A, with ECL dilutions may need to be considerably higher to obtain specific immunolabeling.Immunohistochemistry: 1:500-1:2,500 ELISA: 1:2,500-1:10,00Optimal working dilutions must be dete
Species:	Bovine, Human, Mouse, Rat
Host:	Rabbit
Target:	SYN1
Target description:	synapsin I
Clonality:	Polyclonal

Properties:
	Research Use Only
UNSPSC:	12352203
Storage instructions:	Stable for 1 year at -20-¦C from date of receipt.

Scientific information:
Scientific info:	The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via exocytosis at any one time. Synapsins are encoded by three different genes, synapsin I, II and III, and different neuron terminals will encode different amounts of these, synapsin will make up 1% of total brain protein at any one time.Current studies suggest the following hypothesis for the role of synapsin: synapsins bind synaptic vesicles to components of the cytoskeleton which prevents them from migrating to the presynaptic membrane and releasing transmitter. During an action potential, synapsins are phosphorylated by Ca2+/calmodulin-dependent protein kinase II, releasing the synaptic vesicles and allowing them to move to the membrane and release their neurotransmitter.
Gene ID:	6853

Scientific information:

Scientific info:

The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via exocytosis at any one time. Synapsins are encoded by three different genes, synapsin I, II and III, and different neuron terminals will encode different amounts of these, synapsin will make up 1% of total brain protein at any one time.Current studies suggest the following hypothesis for the role of synapsin: synapsins bind synaptic vesicles to components of the cytoskeleton which prevents them from migrating to the presynaptic membrane and releasing transmitter. During an action potential, synapsins are phosphorylated by Ca2+/calmodulin-dependent protein kinase II, releasing the synaptic vesicles and allowing them to move to the membrane and release their neurotransmitter.

Gene ID:

6853

Additional information:
Synonyms:	AB1543P; Merck (Millipore)

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Product specifications for - Anti-Synapsin I Antibody