anti-ZBP1, mAb (Zippy-1)

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Product specifications for - anti-ZBP1, mAb (Zippy-1)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoCytoChemistry; ImmunoPrecipitation; Western Blot
Species:	Human, Mouse
Target:	ZBP1
Target description:	Z-DNA binding protein 1
Isotype:	IgG2a
Source:	Purified from concentrated hybridoma tissue culture supernatant.

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	-20-¦C

Scientific information:
Scientific info:	Monoclonal Antibody. Recognizes human and mouse ZBP1. Isotype: Mouse IgG2a. Clone: Zippy-1. Applications: ICC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection. - ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection.
Clone ID:	Zippy-1
Gene ID:	81030
Swiss prot ID:	Q9H171

Safety information:
MSDS:	MSDS

Additional information:
Synonyms:	C20orf183; DAI; DLM1; DLM-1; DNA-dependent activator of IRFs; tumor stroma and activated macrophage protein DLM-1; Z-DNA-binding protein 1

ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways: T. Kuriakose, et al.; Sci. Immunol. 1, aag2045 (2016)

DAI senses Influenza A virus genomic RNA and activates RIPK3-dependent cell death: R.J. Thapa, et al.; Cell Host & Microbe 20, 674 (2016)

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Product specifications for - anti-ZBP1, mAb (Zippy-1)