APEX1 antibody, PAb

Biorbyt

APEX1 antibody, PAb

16

Western Blot, ImmunoHistoChemistry

Western blot - 0.1-0.5 μg/ml - Human, Mouse, Rat - - - Immunohistochemistry(Paraffin-embedded Section) - 0.5-1 μg/ml - Human, Rat - Mouse - By Heat WB, IHC

Research Use Only

Polyclonal

500 ug/ml

Rabbit

IgG

Rabbit Polyclonal to APEX1. APEX1, also called apurinic endonuclease (APE), is a DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease, 3-prime,5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The human APEX1 gene consists of 5 exons spanning 2.64 kb and exists as a single copy in the haploid genome. Using in situ hybridization, the APEX1 gene is mapped to 14q11.2-q12. The predicted APEX1 protein, which contained probable nuclear transport signals, was identified as a member of a family of DNA repair enzymes found in lower organisms. The abundance of the large form of APEX1 was increased in leiomyoma extracts relative to myometrial tissue extracts, and the large form was dominant in cell lines derived from leiomyosarcomas.The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases.

Hamster, Human, Mouse, Rat

2°C to 8°C,-20°C

12352203