Overview
- SupplierGeneTex
- Product NameASK1 antibody [C2C3-2], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionMitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing. Ghosh MC et al., 2017 May 19, Sci RepRead more
- Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice. Makena PS et al., 2012 Apr, Am J Respir Cell Mol BiolRead more
- Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide. Chiu SC et al., 2012, PLoS OneRead more
- PM2.5 facilitates IL-6 production in human osteoarthritis synovial fibroblasts via ASK1 activation. Liu JF et al., 2021 Mar, J Cell PhysiolRead more
- The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis. Zhang P et al., 2018 Jan, Nat MedRead more
- The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX et al., 2016 Jun 1, Nat CommunRead more
- USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling. Zhou J et al., 2019 Jan 31, Clin Sci (Lond)Read more