GTX48719 WB Image
ASPP1 antibody - KO/KD, Orthogonal, Overexpression Validated
GTX48719
Overview
- SupplierGeneTex
- Product NameASPP1 antibody - KO/KD, Orthogonal, Overexpression Validated
- Delivery Days Customer10
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.33 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63- and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo.
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203