ATR Antibody

Catalog number: MBS7046132_0,05mg
Brand: MyBioSource
Packing: 0,05 mg
Other sizes: Other sizes available, please contact us.
Price: € 215.00
Expected delivery time: 21 days
Immunohistochemistry (IHC)
Immunohistochemistry of paraffin-em...

Product specifications for - ATR Antibody

Product group: Antibodies
Category: Primary Antibodies
Application: ELISA (EIA), Immunohistochemistry (IHC)
Host: Rabbit
Target: ATR
Target description: ATR serine/threonine kinase
Clonality: Polyclonal
Isotype: IgG
Purity: >95%, Protein G purified
Molecular weight: 297479 Da
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: Liquid
Storage instructions: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze.
Scientific information: 
Scientific info: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
Gene ID: 545
Swiss prot ID: Q13535
Additional information: 
Synonyms: FCTCS; FRP1; MEC1; SCKL; SCKL1; serine/threonine-protein kinase ATR; FRAP-related protein-1; MEC1, mitosis entry checkpoint 1, homolog; ataxia telangiectasia and Rad3-related protein