GTX128145 IP Image
GTX128145 IP Image
ATR (phospho Thr1989) antibody
GTX128145
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameATR (phospho Thr1989) antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.5 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. Hu L et al., 2018 Mar 15, J ImmunolRead more
- A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Tan SLW et al., 2017 Jun 1, CellRead more
- A subset of CB002 xanthine analogs bypass p53-signaling to restore a p53 transcriptome and target an S-phase cell cycle checkpoint in tumors with mutated-p53. Hernandez Borrero L et al., 2021 Jul 29, ElifeRead more
- Age-related dysfunction of the DNA damage response in intestinal stem cells. Watanabe K et al., 2019, Inflamm RegenRead more
- An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells. Alghoul E et al., 2021 Sep 17, STAR ProtocRead more
- ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A. Williamson CT et al., 2016 Dec 13, Nat CommunRead more
- ATR is a MYB regulated gene and potential therapeutic target in adenoid cystic carcinoma. Andersson MK et al., 2020 Jan 30, OncogenesisRead more
- ATR Kinase Activity Limits Mutagenesis and Promotes the Clonogenic Survival of Quiescent Human Keratinocytes Exposed to UVB Radiation. Shaj K et al., 2020 Jan, Photochem PhotobiolRead more
- ATR kinase inhibition sensitizes quiescent human cells to the lethal effects of cisplatin but increases mutagenesis. Hutcherson RJ et al., 2019 Nov, Mutat ResRead more
- ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition. Rainey MD et al., 2020 Sep 1, Cell RepRead more