Overview
- SupplierGeneTex
- Product NameATRX antibody [C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.14 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. Yuan Q et al., 2014, Int J NanomedicineRead more
- Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Raghunandan M et al., 2020 May 8, Hum Mol GenetRead more
- Is H3K27me3 status really a strong prognostic indicator for pediatric posterior fossa ependymomas? A single surgeon, single center experience. Tanrikulu B et al., 2020 May, Childs Nerv SystRead more
- Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. Elmaci I et al., 2017 Nov/Dec, Clin NeuropatholRead more