Overview
- SupplierGeneTex
- Product NameAutotaxin antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.13 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5 end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors. Pleli T et al., 2018, Cell Physiol BiochemRead more
- Association of autotaxin and lysophosphatidic acid receptor 3 with aggressiveness of human breast carcinoma. Popnikolov NK et al., 2012 Dec, Tumour BiolRead more
- Autotaxin stimulates LPA2 receptor in macrophages and exacerbates dextran sulfate sodium-induced acute colitis. Wang Z et al., 2020 Dec, J Mol Med (Berl)Read more
- High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. Huang YL et al., 2018, Cell Physiol BiochemRead more
- Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro. Tsukahara T et al., 2020 Feb 28, Sci RepRead more
- Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion. Geng H et al., 2021 Mar 1, Am J Physiol Renal PhysiolRead more