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GTX46035 FACS Image
GTX46035 FACS Image
GTX46035 FACS Image

Bcl-X antibody [7B2.5] (PE) - Orthogonal Validated

Research Use Only
GTX46035
GeneTex
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityHuman, Mouse
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    Bcl-X antibody [7B2.5] (PE) - Orthogonal Validated
  • Delivery Days Customer
    10
  • Applications
    Flow Cytometry, ImmunoPrecipitation, Western Blot
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    7B2.5
  • Concentration
    0.1 mg/ml
  • Conjugate
    RPE
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure. Nilsonne G et al., 2009 Jun 29, J Exp Clin Cancer Res
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  • Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL). Badr G et al., 2010, Cell Immunol
    Read more