Bcl-X antibody

Catalog number: GTX105661_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: 25 ul
Price: € 334.00
Expected delivery time: 10 days
Quantity:
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Product specifications for - Bcl-X antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; ImmunoPrecipitation; Western Blot
Host: Rabbit
Target: BCL2L1
Target description: BCL2 like 1
Clonality: Polyclonal
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.95 mg/ml
Storage instructions: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Scientific information: 
Scientific info: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq]
Gene ID: 598
Swiss prot ID: Q07817
Additional information: 
Synonyms: apoptosis regulator Bcl-X; BCL2L; bcl-2-like protein 1; Bcl-X; BCLX; BCL-XL/S; PPP1R52; protein phosphatase 1, regulatory subunit 52
"An alternative splicing network links cell-cycle control to apoptosis." Moore MJ et al., 2010 Aug 20, Cell Read more
"Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species." Lee CW et al., 2019 Aug, J Cell Physiol Read more
"Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells." Lee CF et al., 2018 Sep, Biomedicine (Taipei) Read more
"Caspase-3 cleaved p65 fragment dampens NF-kappaB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction." Wier EM et al., 2015 Nov 30, FEBS Lett Read more
"Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro." Huang YT et al., 2016 Jan, Int J Mol Med Read more
"Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells." Chen MF et al., 2016 Jul 26, BMC Cancer Read more
"Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-kappaB activation." Fu K et al., 2016 Jul 25, Elife Read more
"Sam68/KHDRBS1-dependent NF-kappaB activation confers radioprotection to the colon epithelium in gamma-irradiated mice." Fu K et al., 2016 Dec 20, Elife Read more
"The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death." Chen PH et al., 2016 Nov, Neuropharmacology Read more