BCR antibody

Biorbyt

BCR antibody

16

WB: 1:500-2000, IHC-P: 1:50-100 IHC-P, WB

Research Use Only

IgG

Rabbit polyclonal antibody to BCR. The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.

-20°C

12352203