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GTX103259 IHC-P Image
GTX103259 IHC-P Image
GTX103259 IHC-P Image

BIN1 antibody

Research Use Only
GTX103259
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    BIN1 antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    2.35 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Chan Wah Hak L et al., 2018 Sep, Nat Cell Biol
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  • Generation and quantitative proteomics analysis of CK2alpha/alpha(-/-) cells. Borgo C et al., 2017 Feb 17, Sci Rep
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