Overview
- SupplierGeneTex
- Product NameBmi1 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionComponent of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma. Lai YJ et al., 2019 Jun, J Cell PhysiolRead more
- Depletion of p21-activated kinase 1 up-regulates the immune system of APCdelta14/+ mice and inhibits intestinal tumorigenesis. Huynh N et al., 2017 Jun 19, BMC CancerRead more
- Endothelial Cells Promote Formation of Medulloblastoma Stem-Like Cells via Notch Pathway Activation. Wang Y et al., 2017 Oct, J Mol NeurosciRead more
- Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets. Chien CH et al., 2019 Oct 19, J Biomed SciRead more
- Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells. Ju SY et al., 2015 Jul 2, Cell Death DisRead more
- MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance. Ko CY et al., 2018 Apr, Mol NeurobiolRead more
- NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma. Huang CF et al., 2017 Sep 2, J Exp Clin Cancer ResRead more
- Sphere-forming-like cells (squamospheres) with cancer stem-like cell traits from VX2 rabbit buccal squamous cell carcinoma. Chen YK et al., 2014 Dec, Int J Oral SciRead more
- Stress stimuli induce cancer-stemness gene expression via Sp1 activation leading to therapeutic resistance in glioblastoma. Chang KY et al., 2017 Nov 4, Biochem Biophys Res CommunRead more
- Suberoylanilide hydroxamic acid represses glioma stem-like cells. Hsu CC et al., 2016 Nov 18, J Biomed SciRead more