GTX102453 IHC-P Image
GTX102453 IHC-P Image
BMPR1B antibody [N3C3]
GTX102453
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameBMPR1B antibody [N3C3]
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.1 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Downregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma. Yoshino H et al., 2018 Jan, Oncol RepRead more
- Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a. Chung D et al., 2015 Jan 15, Mol Cell EndocrinolRead more
- Expression of receptors for BMP15 is differentially regulated in dominant and subordinate follicles during follicle deviation in cattle. Gasperin BG et al., 2014 Jan 30, Anim Reprod SciRead more