GTX70111 IHC-P Image
BRCA1 antibody [17F8] - ChIP grade - KO/KD Validated
GTX70111
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierGeneTex
- Product NameBRCA1 antibody [17F8] - ChIP grade - KO/KD Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID17F8
- Concentration1.55 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThis gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. Oishi H et al., 2006 Jan 6, J Biol ChemRead more
- ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. de Toledo SM et al., 2000 Dec 14, OncogeneRead more
- BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. Bernard-Gallon DJ et al., 2001, Breast Cancer ResRead more
- BRCA1 and BRCA2 proteins are expressed in milk fat globules. Bernard-Gallon DJ et al., 1999 May 31, Int J CancerRead more
- BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220. Wada O et al., 2004 Aug 5, OncogeneRead more
- BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-beta Responses. Dutta D et al., 2015 Jun, PLoS PathogRead more
- BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Ongusaha PP et al., 2003 Jun 12, OncogeneRead more
- Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? Bosviel R et al., 2012 May, OMICSRead more
- Casticin Induces DNA Damage and Impairs DNA Repair in Human Bladder Cancer TSGH-8301 Cells. Huang AC et al., 2019 Apr, Anticancer ResRead more
- Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells. Shih YL et al., 2016 Oct, Oncol RepRead more