GTX84771 ICC/IF Image
BUB1B antibody [5D9] - Overexpression Validated
GTX84771
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey
Overview
- SupplierGeneTex
- Product NameBUB1B antibody [5D9] - Overexpression Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5D9
- Concentration1.2 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionEssential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
- ReactivityHuman, Monkey
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Predictive and prognostic values of BubR1 and synuclein-gamma expression in breast cancer. Cirak Y et al., 2015, Int J Clin Exp PatholRead more