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GTX84771 ICC/IF Image
GTX84771 ICC/IF Image
GTX84771 ICC/IF Image

BUB1B antibody [5D9] - Overexpression Validated

Research Use Only
GTX84771
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Monkey
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    BUB1B antibody [5D9] - Overexpression Validated
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5D9
  • Concentration
    1.2 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
  • Reactivity
    Human, Monkey
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Predictive and prognostic values of BubR1 and synuclein-gamma expression in breast cancer. Cirak Y et al., 2015, Int J Clin Exp Pathol
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