Calcineurin A antibody, PAb (APC)

Biorbyt

Calcineurin A antibody, PAb (APC)

10

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1000), ICC/IF (1:120), IHC (1:100) ICC, IP, WB, IHC

Research Use Only

Polyclonal

1 mg/ml

APC

Rabbit

Rabbit polyclonal to Calcineurin A (APC). Calcineurin is a heterodimeric phosphatase protein, also known as calcium-dependent serine-threonine phosphatase. The structure consists of a catalytic subunit alpha, Calcineurin A (57-59KDa) the active site and a Ca2+ binding unit, Calcineurin B (19-20KDa) the regulatory subunit(1). Calcineurin plays a key role in the T-cell response growth and differentiation mechanism, regulating the activation of the Nuclear factor of activated T-cells (NFATc) which are important in the expression of IL-2 genes. Calcineurin has been the target of inhibitors, the novel and structural immune-suppressants antifungal drugs(2). Genetic studies in yeast and fungi established the molecular basis of the inhibition mechanism by cyclosporine A and FK506..

Canine, Human, Mouse, Rabbit, Rat

2°C to 8°C

12352203