Overview
- SupplierGeneTex
- Product NameCalreticulin antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.2 mg/ml
- IsotypeIgG
- Scientific DescriptionCalreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Singh N et al., 2016 Aug 1, Dis Model MechRead more
- Composition of receptor tyrosine kinase-mediated lipid micro-domains controlled by adaptor protein interaction. Rohwedder A et al., 2021 Mar 17, Sci RepRead more
- Dual mechanisms regulate the nucleocytoplasmic localization of human DDX6. Huang JH et al., 2017 Feb 20, Sci RepRead more
- EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog. Tang HY et al., 2014, PLoS OneRead more
- Genetic ablation of N-linked glycosylation reveals two key folding pathways for R345W fibulin-3, a secreted protein associated with retinal degeneration. Hulleman JD et al., 2015 Feb, FASEB JRead more
- Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Law CH et al., 2013 Jan 7, ToxicologyRead more
- Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy. Kuo SM et al., 2017 Jun 13, MBioRead more
- The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis. Fucci C et al., 2020 Sep 22, Cell RepRead more