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GTX128428 IHC-P Image
GTX128428 IHC-P Image
GTX128428 IHC-P Image

Carbonic Anhydrase IX antibody

Research Use Only
GTX128428
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Carbonic Anhydrase IX antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.47 mg/ml
  • Isotype
    IgG
  • Scientific Description
    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • 3UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma. Hua KT et al., 2017 Jun 30, Sci Rep
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  • 5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells. Guo X et al., 2017 Jul 7, Sci Rep
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  • Comparison of 18F-fluoroazomycin-arabinofuranoside and 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) in preclinical models of cancer. Valtorta S et al., 2013 Jul, J Nucl Med
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  • Hypoxia-targeting dendritic MRI contrast agent based on internally hydroxy dendrimer for tumor imaging. Han Y et al., 2019 Aug, Biomaterials
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  • Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer. Kang HS et al., 2020 Feb 5, Sci Rep
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  • Rhapontigenin inhibits TGF-beta-mediated epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway and is not associated with HIF-1alpha degradation. Yeh YH et al., 2016 May, Oncol Rep
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