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GTX14367 WB Image
GTX14367 WB Image
GTX14367 WB Image

Caspase 1 antibody [14F468]

Research Use Only
GTX14367
GeneTex
ApplicationsFlow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    Caspase 1 antibody [14F468]
  • Delivery Days Customer
    10
  • Applications
    Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    14F468
  • Concentration
    1 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis. Haldar S et al., 2016 Dec 20, Sci Rep
    Read more
  • Long Non-coding RNA MEG3 Promotes Renal Tubular Epithelial Cell Pyroptosis by Regulating the miR-18a-3p/GSDMD Pathway in Lipopolysaccharide-Induced Acute Kidney Injury. Deng J et al., 2021, Front Physiol
    Read more
  • Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Kolb R et al., 2016 Oct 6, Nat Commun
    Read more
  • Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells. Cheng R et al., 2020 Feb, Oncogene
    Read more