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CaV1.2 antibody, MAb (HRP)

Research Use Only
ORB148163
Biorbyt
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, Other Application
Product group Antibodies
ReactivityHamster, Human, Mouse, Rat
TargetCACNA1C
Price on request
Packing Size
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Overview

  • Supplier
    Biorbyt
  • Product Name
    CaV1.2 antibody, MAb (HRP)
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, Other Application
  • Applications Supplier
    WB (1:1000), IHC (1:1000), ICC/IF (1:100), IP (1:200) AM, ICC, IP, WB, IHC
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    S57
  • Concentration
    1 mg/ml
  • Conjugate
    HRP
  • Gene ID100101555
  • Target name
    CACNA1C
  • Target description
    calcium voltage-gated channel subunit alpha1 C
  • Target synonyms
    CACB; CaCB receptor; calcium channel, voltage-dependent, L type, alpha 1C subunit; CaV1.2; smooth muscle calcium channel blocker; voltage-dependent L-type calcium channel subunit alpha-1C
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Mouse monoclonal to CaV1 (HRP). 2. Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on an ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels. Specifically, Cav1. 2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothys syndrome and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well....
  • Reactivity
    Hamster, Human, Mouse, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203