CBFA2T2 Rabbit pAb

Catalog number: A7033_20ul
Brand: ABClonal
Packing: 20 ul
Price: € 149.00
Expected delivery time: 12 days
Quantity:

Product specifications for - CBFA2T2 Rabbit pAb

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Storage instructions: Store at -20-¦C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Scientific information: 
Scientific info: In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.