Bio-Connect

CBL antibody, PAb

Research Use Only
ORB67165
Biorbyt
ApplicationsWestern Blot
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    CBL antibody, PAb
  • Delivery Days Customer
    16
  • Applications
    Western Blot
  • Applications Supplier
    WB:1:500-1:2000 WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Rabbit polyclonal to CBL.E3 ubiquitin-protein ligase CBL is an adapter protein that functions as a negative regulator of manysignaling pathways that are triggered by activation of cell surface receptors. It acts as an E3 ubiquitinproteinligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and thentransfers it to substrates promoting their degradation by the proteasome. CBL plays an important rolein the regulation of osteoblast differentiation and apoptosis and is essential for osteoclastic boneresorption. Defects in CBL are the cause of Noonan syndrome-like disorder with or without juvenilemyelomonocytic leukemia (NSLL).
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203