Bio-Connect
GTX109835 WB Image
GTX109835 WB Image
GTX109835 WB Image

CCM2 antibody [N1C2]

Research Use Only
GTX109835
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    CCM2 antibody [N1C2]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.4 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203