CD162 Antibody / P selectin glycoprotein ligand 1 / PSGL-1

Biorbyt

CD162 Antibody / P selectin glycoprotein ligand 1 / PSGL-1

16

ImmunoHistoChemistry

Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT IHC-P

Research Use Only

PSGL1/1601

IgG

P selectin glycoprotein ligand 1 (PSGL-1), also called CD162 glycoprotein, functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.

12352203