CD299 antibody, N-term

Catalog number: GTX47033_100ug
Brand: GeneTex
Packing: 100 ug
Price: € 369.00
Expected delivery time: 10 days
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Product specifications for - CD299 antibody, N-term

Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species: Human
Host: Rabbit
Target: CLEC4M
Target description: C-type lectin domain family 4 member M
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Controle: HepG2
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.5-1 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Gene ID: 10332
Swiss prot ID: Q9H2X3
Additional information: 
Synonyms: CD209 antigen-like protein 1; CD209L; CD299; CD299 antigen; C-type lectin domain family 4 member M; DC-SIGN2; DCSIGNR; DC-SIGNR; DC-SIGN-related protein; dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; L-SIGN; mannose binding C-type lectin DC-SIGNR