CD40 antibody

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Product specifications for - CD40 antibody

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Frozen; ImmunoHistoChemistry Parrafin; Western Blot
Species:	Human
Host:	Rabbit
Target:	CD40
Target description:	CD40 molecule
Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Controle:	K562 , THP-1

Properties:
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	0.77 mg/ml
Storage instructions:	2-¦C to 8-¦C, -20-¦C or -80-¦C

Scientific information:
Scientific info:	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
Gene ID:	958
Swiss prot ID:	P25942

Additional information:
Synonyms:	B cell surface antigen CD40; B cell-associated molecule; B-cell surface antigen CD40; Bp50; CD40 molecule, TNF receptor superfamily member 5; CD40L receptor; CDW40; p50; TNFRSF5; tumor necrosis factor receptor superfamily member 5

"Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes." Wang YL et al., 2016 Sep 16, Biochem Biophys Res Commun

"Regulation of CD40 signaling in colon cancer cells and its implications in clinical tissues." Zhou Y et al., 2016 Aug, Cancer Immunol Immunother

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Product specifications for - CD40 antibody