GTX101447 ICC/IF Image
GTX101447 ICC/IF Image
CD40 antibody
GTX101447
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameCD40 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.77 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- C4b-binding protein alpha-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer. Sasaki K et al., 2021 Jun 24, J Exp Clin Cancer ResRead more
- Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes. Wang YL et al., 2016 Sep 16, Biochem Biophys Res CommunRead more
- Regulation of CD40 signaling in colon cancer cells and its implications in clinical tissues. Zhou Y et al., 2016 Aug, Cancer Immunol ImmunotherRead more