Bio-Connect

CD80 Antibody

Research Use Only
ORB386038
Biorbyt
ApplicationsELISA
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Biorbyt
  • Product Name
    CD80 Antibody
  • Delivery Days Customer
    16
  • Applications
    ELISA
  • Applications Supplier
    ELISA (order BSA/sodium azide-free format for coating) ELISA
  • Certification
    Research Use Only
  • Clone ID
    C80/1608
  • Isotype
    IgG
  • Scientific Description
    T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.
  • UNSPSC
    12352203