CD86 Antibody
ORB533979
Overview
- SupplierBiorbyt
- Product NameCD86 Antibody
- Delivery Days Customer16
- ApplicationsFlow Cytometry
- Applications SupplierWestern blot: 1-2ug/ml,Flow cytometry: 1-2ug/million cells,Immunofluorescence/Immunocytochemistry: 2-4ug/ml,Immunohistochemistry (FFPE): 2-4ug/ml for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1) FACS, ICC, IF, IHC-P, WB
- CertificationResearch Use Only
- Clone IDCDLA86-2R
- IsotypeIgG
- Scientific DescriptionRecognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkins disease.
- UNSPSC12352203