GTX102993 ICC/IF Image
GTX102993 ICC/IF Image
CDK4 antibody
GTX102993
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameCDK4 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- Cell-Cycle Proteins Control Production of Neutrophil Extracellular Traps. Amulic B et al., 2017 Nov 20, Dev CellRead more
- Cephalochromin induces G0/G1 cell cycle arrest and apoptosis in A549 human non-small-cell lung cancer cells by inflicting mitochondrial disruption. Hsiao CJ et al., 2014 Apr 25, J Nat ProdRead more
- Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells. Chang HY et al., 2014 Nov 27, Cell Death DisRead more
- Fibroblast growth factor 9 (FGF9) regulation of cyclin D1 and cyclin-dependent kinase-4 in ovarian granulosa and theca cells of cattle. Totty ML et al., 2017 Jan 15, Mol Cell EndocrinolRead more
- Flavopereirine induces cell cycle arrest and apoptosis via the AKT/p38 MAPK/ERK1/2 signaling pathway in human breast cancer cells. Yeh HT et al., 2019 Nov 15, Eur J PharmacolRead more
- Hinokitiol Negatively Regulates Immune Responses through Cell Cycle Arrest in Concanavalin A-Activated Lymphocytes. Chung CL et al., 2015, Evid Based Complement Alternat MedRead more
- Irisin, an exercise myokine, potently suppresses tumor proliferation, invasion, and growth in glioma. Huang CW et al., 2020 Jul, FASEB JRead more
- Licochalcone A attenuates glioma cell growth in vitro and in vivo through cell cycle arrest. Lu WJ et al., 2018 Aug 15, Food FunctRead more