CENP-A antibody, MAb (ATTO-488)

Biorbyt

CENP-A antibody, MAb (ATTO-488)

10

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

WB (1:1000), ICC/IF (1:100) ICC, WB

Research Use Only

Monoclonal

5A7-2E11

1 mg/ml

Atto 488

Mouse

IgG1

Mouse monoclonal to CENP-A (ATTO-488). A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome..

Human

2°C to 8°C

12352203