CENP-A antibody, MAb (HRP)
ORB148112
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
Overview
- SupplierBiorbyt
- Product NameCENP-A antibody, MAb (HRP)
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- Applications SupplierWB (1:1000), ICC/IF (1:100) ICC, WB
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5A7-2E11
- Concentration1 mg/ml
- ConjugateHRP
- HostMouse
- IsotypeIgG1
- Scientific DescriptionMouse monoclonal to CENP-A (HRP). A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome..
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203