Bio-Connect
GTX134464 WB Image
GTX134464 WB Image
GTX134464 WB Image

CLOCK antibody

Research Use Only
GTX134464
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    CLOCK antibody
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    0.57 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203