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GTX102996 ICC/IF Image
GTX102996 ICC/IF Image
GTX102996 ICC/IF Image

COL1A2 antibody [C2C3], C-term

Research Use Only
GTX102996
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    COL1A2 antibody [C2C3], C-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    2.61 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Flavones hydroxylated at 5, 7, 3 and 4 ameliorate skin fibrosis via inhibiting activin receptor-like kinase 5 kinase activity. Zhang Y et al., 2019 Feb 11, Cell Death Dis
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  • Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway. Wu YJ et al., 2020, Int J Med Sci
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  • Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-beta receptor type I. Li H et al., 2016 Oct, Biomed Pharmacother
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