GTX102996 ICC/IF Image
COL1A2 antibody [C2C3], C-term
GTX102996
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameCOL1A2 antibody [C2C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration2.61 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Flavones hydroxylated at 5, 7, 3 and 4 ameliorate skin fibrosis via inhibiting activin receptor-like kinase 5 kinase activity. Zhang Y et al., 2019 Feb 11, Cell Death DisRead more
- Hinokitiol reduces tumor metastasis by inhibiting heparanase via extracellular signal-regulated kinase and protein kinase B pathway. Wu YJ et al., 2020, Int J Med SciRead more
- Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-beta receptor type I. Li H et al., 2016 Oct, Biomed PharmacotherRead more